The microscopy techniques of the OCTOPUS facility allow incredibly precise measurements of biological samples. The microscopes are able to detect even single molecules fluorescing and can image molecular processes within cells to resolutions of tens of nanometres.
Examples of Recent Publications
Metabolons on the Plant ER (2018)
Kriechbaumer V., Botchway S.W. (2018) Metabolons on the Plant ER. In: Hawes C., Kriechbaumer V. (eds) The Plant Endoplasmic Reticulum. Methods in Molecular Biology, vol 1691. Humana Press, New York, NY
Multimodal super-resolution optical microscopy using a transition metalbased probe provides unprecedented capabilities for imaging both nuclear chromatin and mitochondria (2017)
Sreejesh Sreedharan, Martin Gill, Esther Garcia, Hiwa K. Saeed, Darren Robinson, Aisling Byrne, Ashley James Cadby, Tia E. Keyes, Carl G W Smythe, Patrina Pellett, Jorge Bernardino de la Serna, and Jim Antony Thomas
Journal of the American Chemical Society Just Accepted Manuscript
DOI: 10.1021/jacs.7b08772
Super-Resolution Nanoscopy Imaging Applied to DNA Double-Strand Breaks (2017)
Sofia D'Abrantes, Sarah Gratton, Pamela Reynolds, Verena Kriechbaumer, Joseph McKenna, Stephen Barnard, Dave Clarke, and Stanley W. Botchway (2017) Super-Resolution Nanoscopy Imaging Applied to DNA Double-Strand Breaks. Radiation Research In-Press.
Fluorescence-Lifetime Imaging and Super-Resolution Microscopies Shed Light on the Directed- and Self-Assembly of Functional Porphyrins onto Carbon Nanotubes and Flat Surfaces (2017)
Quantifying Secondary Structure Changes in Calmodulin Using 2D-IR Spectroscopy (2017)
Quantifying Secondary Structure Changes in Calmodulin Using 2D-IR Spectroscopy
Lucy Minnes, Daniel J. Shaw, Benjamin P. Cossins, Paul M. Donaldson, Gregory M. Greetham, Michael Towrie, Anthony W. Parker, Matthew J. Baker, Alistair J. Henry, Richard J. Taylor, and Neil T. Hunt
Analytical Chemistry 2017 89 (20), 10898-10906
DOI: 10.1021/acs.analchem.7b02610
Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)2(dppz0] 2+ light-switch compound in solution and when bound to DNA† (2016)
Poynton, F.E., Hall, J.P., Keane, P.M., Schwarz, C., Sazanovich, I.V., Towrie, M., Gunnlaugsson, T., Cardin, C.J., Cardin, D.J., Quinn, S.J. and Long, C., 2016. Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru (phen) 2 (dppz)] 2+ light-switch compound in solution and when bound to DNA. Chemical Science, 7(5), pp.3075-3084.
Enantiomeric Conformation Controls Rate and Yield of Photoinduced Electron Transfer in DNA Sensitized by Ru(II) Dipyridophenazine Complexes (2015)
Keane, P.M., Poynton, F.E., Hall, J.P., Clark, I.P., Sazanovich, I.V., Towrie, M., Gunnlaugsson, T., Quinn, S.J., Cardin, C.J. and Kelly, J.M., 2015. Enantiomeric conformation controls rate and yield of photoinduced electron transfer in DNA sensitized by Ru (II) Dipyridophenazine complexes. Journal of Physical Chemistry Letters, 6(4), pp.734-738.
